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A functional motif of long noncoding RNA Nron against osteoporosis by Jin, Fujun (author);Li, Junhui (author);Zhang, Yong-Biao (author);Liu, Xiangning (author);Cai, Mingxiang (author);Liu, Meijing (author);Li, Mengyao (author);Ma, Cui (author);Yue, Rui (author);Zhu, Yexuan (author);Lai, Renfa (author);Wang, Zuolin (author);Ji, Xunming (author);Wei, Huawei (author);Dong, Jun (author);Liu, Zhiduo (author);Wang, Yifei (author);Sun, Yao (author);Wang, Xiaogang (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A functional motif of long noncoding RNA Nron against osteoporosis about?

Long noncoding RNAs are widely implicated in diverse disease processes. Nonetheless, their regulatory roles in bone resorption are undefined. Here, we identify lncRNA Nron as a critical suppressor of bone resorption. We demonstrate that osteoclastic Nron knockout mice exhibit an osteopenia phenotype with elevated bone resorption activity. Conversely, osteoclastic Nron transgenic mice exhibit lower bone resorption and higher bone mass. Furthermore, the pharmacological overexpression of Nron inhibits bone resorption, while caused apparent side effects in mice. To minimize the side effects, we further identify a functional motif of Nron. The delivery of Nron functional motif to osteoclasts effectively reverses bone loss without obvious side effects. Mechanistically, the functional motif of Nron interacts with E3 ubiquitin ligase CUL4B to regulate ERα stability. These results indicate that Nron is a key bone resorption suppressor, and the lncRNA functional motif could potentially be utilized to treat diseases with less risk of side effects.

Who reads A functional motif of long noncoding RNA Nron against osteoporosis?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Jin, Fujun (author);Li, Junhui (author);Zhang, Yong-Biao (author);Liu, Xiangning (author);Cai, Mingxiang (author);Liu, Meijing (author);Li, Mengyao (author);Ma, Cui (author);Yue, Rui (author);Zhu, Yexuan (author);Lai, Renfa (author);Wang, Zuolin (author);Ji, Xunming (author);Wei, Huawei (author);Dong, Jun (author);Liu, Zhiduo (author);Wang, Yifei (author);Sun, Yao (author);Wang, Xiaogang (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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