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Reduced Default Mode Network Connectivity Relative to White Matter Integrity Is Associated with Poor Cognitive Outcomes in Patients with Idiopathic Normal Pressure Hydrocephalus by Shigenori Kanno; Kun-ichi Ogawa; Hiroaki Kikuchi; Masako Toyoshima; Nobuhito Abe; Kazushi Sato; Koichi Miyazawa; Ryuji Oshima; Satoru Ohtomo; Hiroaki Arai; Satoshi Shibuya; Kyoko Suzuki is a Medicine article available to read on EtoBox.

What is Reduced Default Mode Network Connectivity Relative to White Matter Integrity Is Associated with Poor Cognitive Outcomes in Patients with Idiopathic Normal Pressure Hydrocephalus about?

## Background: The aim of this study was to investigate whether default mode network (dmn) connectivity and brain white matter integrity at baseline were associated with severe cognitive impairments at baseline and poor cognitive outcomes after shunt placement in patients with idiopathic normal pressure hydrocephalus (inph). ## Methods: Twenty consecutive patients with inph whose symptoms were followed for 6 months after shunt placement and 10 healthy controls (hcs) were enrolled. dmn connectivity and brain white matter integrity at baseline in the patients with inph and hcs were detected by using resting-state functional magnetic resonance imaging (mri) with independent component analysis and diffusion tensor imaging, respectively, and these mri indexes were compared between the patients with inph and hcs. performance on neuropsychological tests for memory and executive function and on the gait test was assessed in the patients with inph at baseline and 6 months after shunt placement. we divided the patients with inph into the relatively preserved and reduced dmn connectivity groups using the mri indexes for dmn connectivity and brain white matter integrity, and the clinical measu

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Author

Shigenori Kanno; Kun-ichi Ogawa; Hiroaki Kikuchi; Masako Toyoshima; Nobuhito Abe; Kazushi Sato; Koichi Miyazawa; Ryuji Oshima; Satoru Ohtomo; Hiroaki Arai; Satoshi Shibuya; Kyoko Suzuki

Published

2021

Language

EN

Field

Medicine (Health Sciences)