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Interaction of Carbamazepine and Chlorpromazine in Rabbits by Marina D. Rukhadze; Maka M. Alexishvili; Vazha M. Okujava; Teona G. Makharadze; Maya V. Sebiskveradze; Sonya K. Tsagareli is a Chemistry article available to read on EtoBox.

What is Interaction of Carbamazepine and Chlorpromazine in Rabbits about?

The interaction of carbamazepine and chlorpromazine in rabbits has been studied. The drugs were administrated as single oral doses (200 mg of each drug). The sequence of administration of the drugs was varied. It has been established that by simultaneous administration these drugs decrease absorption of each other in plasma. This may be explained by competition of the drugs to transfer from the gastrointestinal tract into plasma, as well as by the formation of complexes, more or less stable and more or less bound to gastrointestinal tissues. Carbamazepine intensifies the biotransformation of chlorpromazine, which may be caused by the ability of carbamazepine to induce microsomal liver enzymes. Chlorpromazine suppresses the biotransformation of carbamazepine, however. This may be caused by intensive capture of chlorpromazine by liver tissues and by its intensive biotransformation, which in turn is conditioned by its surface-active nature and by the increase of its metabolism with carbamazepine. Therefore the biotransformation of chlorpromazine is increased and metabolism of carbamazepine is reduced. The sequence of administration of the drugs affects their pharmacokinetics significa

Who reads Interaction of Carbamazepine and Chlorpromazine in Rabbits?

Author

Marina D. Rukhadze; Maka M. Alexishvili; Vazha M. Okujava; Teona G. Makharadze; Maya V. Sebiskveradze; Sonya K. Tsagareli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0269-3879)

Published

1999

Language

EN

Field

Chemistry (Physical Sciences)