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Impact of Gallstone Disease on the Risk of Stroke and Coronary Artery Disease: Evidence from Prospective Observational Studies and Genetic Analyses by Zhang, Li (author);Zhang, Wenqiang (author);He, Lin (author);Cui, Huijie (author);Wang, Yutong (author);Wu, Xueyao (author);Zhao, Xunying (author);Yan, Peijing (author);Yang, Chao (author);Xiao, Changfeng (author);Tang, Mingshuang (author);Chen, Lin (author);Xiao, Chenghan (author);Zou, Yanqiu (author);Liu, Yunjie (author);Yang, Yanfang (author);Zhang, Ling (author);Yao, Yuqin (author);Li, Jiayuan (author);Liu, Zhenmi (author);Yang, Chunxia (author);Jiang, Xia (author);Zhang, Ben (author) is a Medicine article available to read on EtoBox.

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## Background Despite epidemiological evidence associating gallstone disease (GSD) with cardiovascular disease (CVD), a dilemma remains on the role of cholecystectomy in modifying the risk of CVD. We aimed to characterize the phenotypic and genetic relationships between GSD and two CVD events – stroke and coronary artery disease (CAD). ## Methods We first performed a meta-analysis of cohort studies to quantify an overall phenotypic association between GSD and CVD. We then investigated the genetic relationship leveraging the largest genome-wide genetic summary statistics. We finally examined the phenotypic association using the comprehensive data from UK Biobank (UKB). ## Results An overall significant effect of GSD on CVD was found in meta-analysis (relative risk [RR] = 1.26, 95% confidence interval [CI] = 1.19–1.34). Genetically, a positive shared genetic basis was observed for GSD with stroke (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}\_{g}$$\end{document}rg=0.16, __P__ = 6.00 × 10^–4^) and C

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Author

Zhang, Li (author);Zhang, Wenqiang (author);He, Lin (author);Cui, Huijie (author);Wang, Yutong (author);Wu, Xueyao (author);Zhao, Xunying (author);Yan, Peijing (author);Yang, Chao (author);Xiao, Changfeng (author);Tang, Mingshuang (author);Chen, Lin (author);Xiao, Chenghan (author);Zou, Yanqiu (author);Liu, Yunjie (author);Yang, Yanfang (author);Zhang, Ling (author);Yao, Yuqin (author);Li, Jiayuan (author);Liu, Zhenmi (author);Yang, Chunxia (author);Jiang, Xia (author);Zhang, Ben (author)

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)