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Can I read Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria on EtoBox?
Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria by Nam Vo; Hyoung‐Yeon Seo; Andria Robinson; Gwendolyn Sowa; Douglas Bentley; Lauren Taylor; Rebecca Studer; Arvydas Usas; Johnny Huard; Sean Alber; Simon C. Watkins; Joon Lee; Paulo Coehlo; Dong Wang; Mattia Loppini; Paul D. Robbins; Laura J. Niedernhofer; James Kang is a Medicine article available to read on EtoBox.
What is Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria about?
## Abstract Intervertebral disc degeneration (IDD) is a common and debilitating disorder that results in reduced flexibility of the spine, pain, and reduced mobility. Risk factors for IDD include age, genetic predisposition, injury, and other environmental factors such as smoking. Loss of proteoglycans (PGs) contributes to IDD with advancing age. Currently there is a lack of a model for rapid investigation of disc aging and evaluation of therapeutic interventions. Here we examined progression of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1–XPF (__Ercc1__^−/Δ^ mice). The ERCC1‐deficient mice showed loss of disc height and degenerative structural changes in their vertebral bodies similar to those reported for old rodents. Compared to their wild‐type littermates, __Ercc1__^−/Δ^ mice also exhibit other age‐related IDD characteristics, including premature loss of disc PG, reduced matrix PG synthesis, and enhanced apoptosis and cell senescence. Finally, the onset of age‐associated disc pathologies was further accelerated in __Ercc1__^−/Δ^ mice following chronic treatment with the chemotherapeutic agent mechlorethami
Who reads Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nam Vo; Hyoung‐Yeon Seo; Andria Robinson; Gwendolyn Sowa; Douglas Bentley; Lauren Taylor; Rebecca Studer; Arvydas Usas; Johnny Huard; Sean Alber; Simon C. Watkins; Joon Lee; Paulo Coehlo; Dong Wang; Mattia Loppini; Paul D. Robbins; Laura J. Niedernhofer; James Kang
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)