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The role of sexually transmitted infections in male circumcision effectiveness against HIV – insights from clinical trial simulation by Kamal Desai; Marie-Claude Boily; Geoff P Garnett; Benoît R Mâsse; Stephen Moses; Robert C Bailey is a Mathematics article available to read on EtoBox.
What is The role of sexually transmitted infections in male circumcision effectiveness against HIV – insights from clinical trial simulation about?
## Background A landmark randomised trial of male circumcision (MC) in Orange Farm, South Africa recently showed a large and significant reduction in risk of HIV infection, reporting MC effectiveness of 61% (95% CI: 34%–77%). Additionally, two further randomised trials of MC in Kisumu, Kenya and Rakai, Uganda were recently stopped early to report 53% and 48% effectiveness, respectively. Since MC may protect against both HIV and certain sexually transmitted infections (STI), which are themselves cofactors of HIV infection, an important question is the extent to which this estimated effectiveness against HIV is mediated by the protective effect of circumcision against STI. The answer lies in the trial data if the appropriate statistical analyses can be identified to estimate the separate efficacies against HIV and STI, which combine to determine overall effectiveness. ## Objectives and Methods Focusing on the MC trial in Kisumu, we used a stochastic prevention trial simulator (1) to determine whether statistical analyses can validly estimate efficacy, (2) to determine whether MC efficacy against STI alone can produce large effectiveness against HIV and (3) to estimate the fraction of
Who reads The role of sexually transmitted infections in male circumcision effectiveness against HIV – insights from clinical trial simulation?
It is typically read by researchers, students, and practitioners in Mathematics.
- Author
- Kamal Desai; Marie-Claude Boily; Geoff P Garnett; Benoît R Mâsse; Stephen Moses; Robert C Bailey
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1742-7622)
- Published
- 2006
- Language
- EN
- Field
- Mathematics (Health Sciences)