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Prolonged Febrile Neutropenia in the Pediatric Patient with Cancer by Koh, Andrew Y. is a Medicine article available to read on EtoBox.

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## Overview: Infectious diseases continue to be major causes of morbidity and mortality in pediatric patients with cancer. Yet not all pediatric patients with cancer with fever and neutropenia are at equal risk for substantial morbidity or mortality from infection. Patients at highest risk for developing infectious complications are those with severe and prolonged neutropenia, substantial medical comorbidity, and hematologic malignancy, or recipients of stem-cell transplantation. These “high-risk” patients also have concomitant host immune deficits as well: severe mucositis, lymphopenia, hypogammaglobulinemia, and gut microbial dysbiosis. Because bacterial and fungal infections are the most common infectious complications, continuation of empirical antibacterial antibiotics that were initiated at the onset of febrile neutropenia and prompt initiation of empirical antifungal therapy in the setting of prolonged fever and neutropenia continue to be the standard of care. In high-risk patients, antibiotic therapy should be maintained until neutrophil counts have recovered. Adjunctive therapies have been shown to be ineffective (e.g., colony-stimulating factors) or necessitate further st

Who reads Prolonged Febrile Neutropenia in the Pediatric Patient with Cancer?

Author

Koh, Andrew Y.

Publisher

American Society of Clinical Oncology; American Society of Clinical Oncology (ASCO) (ISSN 1548-8748)

Published

2012

Language

EN

Field

Medicine (Health Sciences)