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Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients by Zahra Moulana; Mojgan Bagherzadeh; Mohammad Mirzakhani; Ali Rostami; Mousa Mohammadnia-Afrouzi; Mehdi Shahbazi is a Environmental Science article available to read on EtoBox.

What is Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients about?

Pentraxin 3 (PTX3) and ficolin are the plasma phase of pattern recognition receptors (PRRs) and can activate complement through classical and lectin pathways, respectively, which may contribute to disease severity. This study aimed to investigate the association between PTX3 and ficolin with disease severity in patients with coronavirus disease-2019 (COVID-19). Seventythree COVID-19 patients and 25 healthy controls were enrolled in this study. The participants were divided into three groups as follows: 14 patients as the intensive care unit (ICU) group, 59 patients as the non-ICU group, and 25 subjects as the healthy control group. The serum levels of PTX3 and ficolin were measured by enzyme-linked immunosorbent assay (ELISA) kits. Patients in ICU and non-ICU groups had significantly higher levels of PTX3 compared to the healthy control group (p = 0.0002 and p = 0.0072, respectively). Patients in the ICU group also had an increased amount of PTX3 (1957 ± 1769 pg/ml) compared to non-ICU patients (1220 ± 1784 pg/ml). However, this difference was not significant. On the other hand, serum levels of ficolin were not different among the three groups. PTX3, as an acute phase protein, may

Who reads Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients?

Author

Zahra Moulana; Mojgan Bagherzadeh; Mohammad Mirzakhani; Ali Rostami; Mousa Mohammadnia-Afrouzi; Mehdi Shahbazi

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Environmental Science (Physical Sciences)