Can I read Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina on EtoBox?

Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina by Harminder D. Singh; Jian-xing Ma; Yusuke Takahashi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina about?

Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt ligands was measured using wild-type and the KO cell lines. The results identified three groups of Wnt ligands based on their co-receptor specificity: 1) activation of Wnt signaling only through LRP6, 2) through both LRP5 and LRP6 and 3) predominantly through LRP5. These results indicate that LRP5 and LRP6 have differential roles in Wnt signaling regulation.

Who reads Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina?

Author

Harminder D. Singh; Jian-xing Ma; Yusuke Takahashi

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)