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Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations by Yang Hu; Jun Li; Biqi Wang; Lu Zhu; Yanping Li; Kerry L Ivey; Kyu Ha Lee; A Heather Eliassen; Andrew Chan; Curtis Huttenhower; Frank B Hu; Qibin Qi; Eric B Rimm; Qi Sun is a Medicine article available to read on EtoBox.
What is Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations about?
## Objectives To identify indolepropionate (IPA)-predicting gut microbiota species, investigate potential diet–microbiota interactions, and examine the prospective associations of circulating IPA concentrations with type 2 diabetes (T2D) and coronary heart disease (CHD) risk in free-living individuals. ## Design We included 287 men from the Men’s Lifestyle Validation Study, a substudy of the Health Professionals Follow-Up Study (HPFS), who provided up to two pairs of faecal samples and two blood samples. Diet was assessed using 7-day diet records. Associations between plasma concentrations of tryptophan metabolites and T2D CHD risk were examined in 13 032 participants from Nurses’ Health Study (NHS), NHSII and HPFS. ## Results We identified 17 microbial species whose abundance was significantly associated with plasma IPA concentrations. A significant association between higher tryptophan intake and higher IPA concentrations was only observed among men who had higher fibre intake and a higher microbial species score consisting of the 17 species (p-interaction<0.01). Dietary and plasma concentrations of tryptophan and most kynurenine pathway metabolites were positively associated wit
Who reads Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yang Hu; Jun Li; Biqi Wang; Lu Zhu; Yanping Li; Kerry L Ivey; Kyu Ha Lee; A Heather Eliassen; Andrew Chan; Curtis Huttenhower; Frank B Hu; Qibin Qi; Eric B Rimm; Qi Sun
- Publisher
- BMJ
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)