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The article details the first total syntheses of the prenylated isoflavones 5-deoxy-3′-prenylbiochanin A and erysubin F from Erythrina sacleuxii, utilizing mono- or di-O-allylated chalcones and hypervalent iodine reagents. The synthesized compounds were tested for antibacterial activity, revealing that while erysubin F and its flavone isomer showed effectiveness against MRSA, 5-deoxy-3′-prenylbiochanin A was inactive. The study highlights the potential of prenylated isoflavones in antimicrobial applications

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teamlanhmanh514

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EN