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The paper discusses an isothiourea-catalyzed Michael addition-lactonisation process using α,β-unsaturated trichloromethyl ketones and carboxylic acids to produce diesters with high diastereo- and enantioselectivity. The method allows for the sequential addition of different nucleophiles, enabling the formation of differentially substituted diacid derivatives. The study highlights the robustness and versatility of trichloromethyl ketones as stable ester equivalents in synthetic organic chemistry.

Author

sreevinaya

Language

EN