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Can I read Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe on EtoBox?
Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe by Sumeera Sidiq; Ravi Ranjan Kumar; Neelima D. Passi; D. K. Dhawan; Jaya Shukla; B. R. Mittal; Vijayta D. Chadha is a Physics and Astronomy article available to read on EtoBox.
What is Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe about?
The present study was designed to unravel the bioevaluation of [ 99m Tc]Tc-GSH in HT 29 colon cancer cell line as well as in experimentally induced colon cancer. The radiochemical yield was observed to be 95.93 ± 1.09%. In silico docking studies revealed that [ 99m Tc]Tc-GSH gets well accommodated in the binding pocket of gamma-glutamyl transpeptidase in comparable orientation with lowest estimated binding energy -81.90. Toxicity assays i.e. 3-(4,5-dimethylthiazolyl-2)-2,5diphenyltetrazolium bromide and trypan blue exclusion assay showed that radiocomplex is non-toxic to HT 29 cells. In conclusion, in vitro and in vivo results indicated the [ 99m Tc]Tc-GSH radiocomplex has tumor delineating features and also exhibits selectivity for colon tumor.
Who reads Evaluation of 99mTc-labeled glutathione as a colon cancer targeting probe?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Sumeera Sidiq; Ravi Ranjan Kumar; Neelima D. Passi; D. K. Dhawan; Jaya Shukla; B. R. Mittal; Vijayta D. Chadha
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)