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Gadolinium Concentrations in Biological Matrices From Patients Exposed to Gadolinium-Based Contrast Agents by Kerry A. Layne; Kishor Raja; Paul I. Dargan; David M. Wood is a Medicine article available to read on EtoBox.

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## Objectives: There is increasing evidence that gd may be retained within the skin, bones, and solid organs in patients with normal renal function after exposure to gd-based contrast agents (gbcas). here we present clinical data from 19 patients who requested referral to our clinical toxicology service for assessment of potential "gd toxicity." ## Materials and methods: Patients had undergone a median of 2 (interquartile range [iqr], 1-5) exposures to gbcas and were reviewed at a median of 5 months (iqr, 2-8 months) after the last gbca exposure. patients had a clinical assessment by a clinical toxicologist, and biological samples were taken in 17 patients (89.5%). gd concentrations were measured in these samples using inductively coupled plasma mass spectrometry. ## Results: All patients had significant comorbidities, and after an extensive clinical review, none of the reported symptoms were considered likely to be related to "gd toxicity." whole blood, plasma, and urine samples had detectable gd concentrations in 69.2%, 78.6%, and 95.2% of samples, respectively. median (iqr) concentrations of gd were as follows: whole blood, 0.013 ng/ml (iqr, limit of detection [lod]-0.884 ng/ml)

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Author

Kerry A. Layne; Kishor Raja; Paul I. Dargan; David M. Wood

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2021

Language

EN

Field

Medicine (Health Sciences)