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Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV by Philipp de Leuw; Christophe T. Arendt; Annette E. Haberl; Daniel Froadinadl; Gerrit Kann; Timo Wolf; Christoph Stephan; Gundolf Schuettfort; Moises Vasquez; Luca Arcari; Hui Zhou; Hafisyatul Zainal; Monika Gawor; Eleftherios Vidalakis; Michael Kolentinis; Moritz H. Albrecht; Felicitas Escher; Thomas J. Vogl; Andreas M. Zeiher; Eike Nagel; Valentina O. Puntmann is a Medicine article available to read on EtoBox.

What is Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV about?

OBJECTIVES The goal of this study was to examine prognostic relationships between cardiac imaging measures and cardiovascular outcome in people living with human immunodeficiency virus (HIV) (PLWH) on highly active antiretroviral therapy (HAART). BACKGROUND PLWH have a higher prevalence of cardiovascular disease and heart failure (HF) compared with the noninfected population. The pathophysiological drivers of myocardial dysfunction and worse cardiovascular outcome in HIV remain poorly understood. METHODS This prospective observational longitudinal study included consecutive PLWH on long-term HAART undergoing cardiac magnetic resonance (CMR) examination for assessment of myocardial volumes and function, T1 and T2 mapping, perfusion, and scar. Time-to-event analysis was performed from the index CMR examination to the first single event per patient. The primary endpoint was an adjudicated adverse cardiovascular event (cardiovascular mortality, nonfatal acute coronary syndrome, an appropriate device discharge, or a documented HF hospitalization). RESULTS A total of 156 participants (62% male; age [median, interquartile range]: 50 years [42 to 57 years]) were included. During a median f

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Author

Philipp de Leuw; Christophe T. Arendt; Annette E. Haberl; Daniel Froadinadl; Gerrit Kann; Timo Wolf; Christoph Stephan; Gundolf Schuettfort; Moises Vasquez; Luca Arcari; Hui Zhou; Hafisyatul Zainal; Monika Gawor; Eleftherios Vidalakis; Michael Kolentinis; Moritz H. Albrecht; Felicitas Escher; Thomas J. Vogl; Andreas M. Zeiher; Eike Nagel; Valentina O. Puntmann

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)