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On September 17, 2024, the FDA approved pembrolizumab (Keytruda) in combination with pemetrexed and platinum chemotherapy as a first-line treatment for unresectable advanced or metastatic malignant pleural mesothelioma. The approval was based on the KEYNOTE-483 trial, which showed a statistically significant improvement in overall survival for patients receiving the combination therapy compared to chemotherapy alone. The median overall survival was 17.3 months for the combination group versus 16.1 months fo
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