Can I read Maternal Antibiotic Administration During a Critical Developmental Window Has Enduring Neurobehavioural Effects in Offspring Mice on EtoBox?

Maternal Antibiotic Administration During a Critical Developmental Window Has Enduring Neurobehavioural Effects in Offspring Mice by Rory O’Connor; Gerard M. Moloney; Christine Fulling; Kenneth J O’Riordan; Pat Fitzgerald; Thomaz F.S. Bastiaanssen; Harriët Schellekens; Timothy G. Dinan; John F. Cryan is a Neuroscience article available to read on EtoBox.

What is Maternal Antibiotic Administration During a Critical Developmental Window Has Enduring Neurobehavioural Effects in Offspring Mice about?

Rates of perinatal maternal antibiotic use have increased in recent years linked to prophylactic antibiotic use following Caesarean section delivery. This antibiotic use is necessary and beneficial in the short-term; however, long-term consequences on brain and behaviour have not been studied in detail. Here, we endeavoured to determine whether maternal administration of antibiotics during a critical window of development in early life has lasting effects on brain and behaviour in offspring mice. To this end we studied two different antibiotic preparations (single administration of Phenoxymethylpenicillin at 31 mg/kg/day; and a cocktail consisting of, ampicillin 1 mg/mL; vancomycin 0.5 mg/mL; metronidazole 1 mg/mL; ciprofloxacin 0.2 mg/mL and imipenem 0.25 mg/mL). It was observed that early life exposure to maternal antibiotics led to persistent alterations in anxiety, sociability and cognitive behaviours. These effects in general were greater in animals treated with the broad-spectrum antibiotic cocktail compared to a single antibiotic with the exception of deficits in social recognition which were more robustly observed in Penicillin V exposed animals. Given the prevalence of mat

Who reads Maternal Antibiotic Administration During a Critical Developmental Window Has Enduring Neurobehavioural Effects in Offspring Mice?

Author

Rory O’Connor; Gerard M. Moloney; Christine Fulling; Kenneth J O’Riordan; Pat Fitzgerald; Thomaz F.S. Bastiaanssen; Harriët Schellekens; Timothy G. Dinan; John F. Cryan

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)