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Quantification of Ureteral Pain Sensation Induced by Kidney Stone by Yonggang Liu; Shaobao Liu; Moxiao Li; Tian Jian Lu is a Engineering article available to read on EtoBox.

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Abstract Pain sensation induced by kidney stone (renal calculi) in ureter, a kind of visceral ducts connecting the kidneys and bladder, critically depends upon the relative size of stone to ureter. To quantify such pain sensation, we draw a parallel analogy between the mechanisms underlying skin/teeth thermal pain (which can be quantified with a holistic pain model consisting of modified Hodgkin-Huxley model and gate control theory) and mechanism of ureteral pain to extend the holistic pain model to stone-blocked ureter. We then perform finite element simulations to obtain key mechanical stresses on ureter wall exerted by a kidney stone having varying size. These stresses are subsequently adopted to calculate the voltage potential of neuron membrane in the holistic pain model and eventually a theoretical framework to quantify the dependence of ureteral pain sensation on stone size is established, for the first time. We demonstrate that ureter pain sensation increases sharply when the diameter of kidney stone becomes 7.5% to 20% larger than the inner diameter of ureter, peaking at ~20% larger; however, increasing further the stone diameter leads only to marginally exacerbated pain s

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Author

Yonggang Liu; Shaobao Liu; Moxiao Li; Tian Jian Lu

Publisher

ASME International

Published

2023

Language

EN

Field

Engineering (Physical Sciences)