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Dynamic alteration of the E‐cadherin/catenin complex during cell differentiation and invasion of undifferentiated‐type gastric carcinomas by Etsuko Nakamura; Hiroyuki Sugihara; Masamichi Bamba; Takanori Hattori is a Medicine article available to read on EtoBox.

What is Dynamic alteration of the E‐cadherin/catenin complex during cell differentiation and invasion of undifferentiated‐type gastric carcinomas about?

## Abstract To examine qualitative alterations of the E‐cadherin/catenin complex (CCC) during cell differentiation and invasion of undifferentiated‐type gastric carcinoma, immunoreactivity for the intracytoplasmic domain and the extracellular domain (ECD) of E‐cadherin, and that of β‐catenin, was analysed in the mucosal, submucosal, and deepest invasive parts of 20 early and 20 advanced cancers that had a component of intramucosal signet ring cell carcinoma. Histological subtype affected the mode of E‐CCC alteration. The tumours with a tubular component and without organized differentiation of signet ring cells in a layered structure were associated with nuclear expression of β‐catenin and may derive from tubular adenocarcinomas through de‐differentiation and de‐regulation of the Wnt pathway. These tumours were characterized by relatively stable ECD expression throughout the course of tumour progression. On the other hand, the tumours with a layered structure, which may derive from signet ring cell carcinoma by __de novo__ abnormality of E‐cadherin, were characterized by dynamic alteration of ECD expression during cell differentiation and tumour progression; intramucosal spread (wi

Who reads Dynamic alteration of the E‐cadherin/catenin complex during cell differentiation and invasion of undifferentiated‐type gastric carcinomas?

Author

Etsuko Nakamura; Hiroyuki Sugihara; Masamichi Bamba; Takanori Hattori

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2005

Language

EN

Field

Medicine (Health Sciences)