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This document presents a network meta-analysis comparing the efficacy of various pharmacological treatments for pityriasis rosea (PR), a self-limiting skin condition often linked to human herpesviruses. The analysis of 12 randomized control trials revealed that acyclovir is the most effective treatment for rash improvement, while oral steroids and their combination with antihistamines are best for itch resolution. The findings suggest that while reassurance and rest are typically recommended, pharmacologica
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