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Graphene-based Sensing of Oxygen Transport Through Pulmonary Membranes by Kim, Mijung; Porras-Gomez, Marilyn; Leal, Cecilia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Graphene-based Sensing of Oxygen Transport Through Pulmonary Membranes about?

Lipid-protein complexes are the basis of pulmonary surfactants covering the respiratory surface and mediating gas exchange in lungs. Cardiolipin is a mitochondrial lipid overexpressed in mammalian lungs infected by bacterial pneumonia. In addition, increased oxygen supply (hyperoxia) is a pathological factor also critical in bacterial pneumonia. In this paper we fabricate a micrometer-size graphene-based sensor to measure oxygen permeation through pulmonary membranes. Combining oxygen sensing, X-ray scattering, and Atomic Force Microscopy, we show that mammalian pulmonary membranes suffer a structural transformation induced by cardiolipin. We observe that cardiolipin promotes the formation of periodic protein–free inter–membrane contacts with rhombohedral symmetry. Membrane contacts, or stalks, promote a significant increase in oxygen gas permeation which may bear significance for alveoli gas exchange imbalance in pneumonia.

Who reads Graphene-based Sensing of Oxygen Transport Through Pulmonary Membranes?

Author

Kim, Mijung; Porras-Gomez, Marilyn; Leal, Cecilia

Publisher

Nature Publishing Group; Springer Science and Business Media LLC; [London]: Nature Publishing Group, 2010-; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 2041-1723)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)