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Assessment of Fibroblast Growth Factor 19 as a Non-invasive Serum Marker for Hepatocellular Carcinoma by Ghada Abdelrahman Mohamed; Ehab Hasan Nashaat; Hadeer Mohamed Fawzy; Ahmed Mohamed ElGhandour is a Medicine article available to read on EtoBox.

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## BACKGROUND Fibroblast growth factor 19 (FGF-19) is one of the founding members of the endocrine FGF subfamily. Recently, it has been the subject of much interest owing to its role in various physiological processes affecting glucose and lipid metabolism and the regulation of bile acid secretion as well as cell proliferation, differentiation, and motility. Additionally, FGF-19 secretion in an autocrine style has reportedly contributed to cancer progression in various types of malignancies including hepatocellular carcinoma (HCC). ## AIM To estimate the serum FGF-19 concentrations in HCC cases and assess its diagnostic performance for the detection of HCC. ## METHODS We recruited 90 adult participants and divided them into three equal groups: Healthy controls, cirrhosis patients, and HCC patients. Serum FGF-19 concentrations were measured using the Human FGF-19 ELISA kit. ## RESULTS We detected a high statistically significant difference in serum FGF-19 levels among the three groups. The highest level was observed in the HCC group, followed by the cirrhosis and control groups (236.44 ± 40.94 __vs__ 125.63 ± 31.54 __vs__ 69.60 ± 20.90 pg/mL, respectively, __P__ ≤ 0.001). FGF-19 was

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Author

Ghada Abdelrahman Mohamed; Ehab Hasan Nashaat; Hadeer Mohamed Fawzy; Ahmed Mohamed ElGhandour

Publisher

Baishideng Publishing Group Inc

Published

2022

Field

Medicine (Health Sciences)