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Characterization and Osteogenic Evaluation of Mesoporous Magnesium–calcium Silicate/polycaprolactone/polybutylene Succinate Composite Scaffolds Fabricated by Rapid Prototyping by Kang, Yun Gyeong; Wei, Jie; Kim, Ji Eun; Wu, Yan Ru; Lee, Eun Jin; Su, Jiacan; Shin, Jung-Woog is a Materials Science article available to read on EtoBox.
What is Characterization and Osteogenic Evaluation of Mesoporous Magnesium–calcium Silicate/polycaprolactone/polybutylene Succinate Composite Scaffolds Fabricated by Rapid Prototyping about?
The properties of scaffolds for bone tissue engineering, including their biocompatibility, highly interconnected porosity, and mechanical integrity, are critical for promoting cell adhesion, proliferation, and osteoinduction. We used various physical and biological assays to obtain __in vitro__ confirmation that the proposed composite scaffolds are potentially suitable for applications to bone tissue engineering. The proposed new composite scaffolds, which we fabricated by a rapid prototyping technique, were composed of mesoporous magnesium–calcium silicate (m\_MCS), polycaprolactone (PCL), and polybutylene succinate (PBSu). We systematically evaluated the characteristics of the composite scaffolds, such as the hydrophilicity and bioactivity. We also investigated the proliferation and osteogenic differentiation of human mesenchymal stem cells (MSCs) scaffolded on the m\_MCS/PCL/PBSu composite. Our results showed that, compared to the m\_MCS/PCL scaffold, the m\_MCS/PCL/PBSu scaffold has improved water absorption, __in vitro__ degradability, biocompatibility, and bioactivity in simulated body fluid, while its mechanical strength is reduced. Moreover, the results of the cytotoxicity
Who reads Characterization and Osteogenic Evaluation of Mesoporous Magnesium–calcium Silicate/polycaprolactone/polybutylene Succinate Composite Scaffolds Fabricated by Rapid Prototyping?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Kang, Yun Gyeong; Wei, Jie; Kim, Ji Eun; Wu, Yan Ru; Lee, Eun Jin; Su, Jiacan; Shin, Jung-Woog
- Publisher
- The Royal Society of Chemistry; Royal Society of Chemistry; Cambridge: RSC Publishing; Royal Society of Chemistry (RSC) (ISSN 2046-2069)
- Published
- 2018
- Language
- EN
- Field
- Materials Science (Physical Sciences)