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Can I read Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions on EtoBox?
Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions by Marouane Ait Lahcen; Mohamed Adardour; Salma Mortada; Mehdi Oubahmane; Samir Hmaimou; Mohamed Loughzail; Ismail Hdoufane; Sanae Lahmidi; My El Abbes Faouzi; Driss Cherqaoui; Joel T. Mague; Abdesselam Baouid is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions about?
We report in this work a synthesis of novel triazolo [1, benzodiazepine derivatives by the 1,3-dipolar cycloaddition reaction of N-aryl-C-ethoxycarbonylnitrilimines with 1,5-benzodiazepines. All the structures of the new compounds were determined from their NMR ( 1 H and 13 C) and HRMS. Then, X-ray crystallography analysis of compound 4d confirmed the stereochemistry of cycloadducts. The compounds 1, 4a-d, 5a-d, 6c, 7 and 8 were evaluated for their in vitro anti-diabetic activity against a-glucosidase. The compounds 1, 4d, 5a and 5b showed potential inhibitory activities compared to standard acarbose. Additionally, an in silico docking study was conducted to look into the active binding mode of the synthesized compounds within the target enzyme.
Who reads Synthesis, characterization, X-ray, α-glucosidase inhibition and molecular docking study of new triazolic systems based on 1,5-benzodiazepine via 1,3-dipolar cycloaddition reactions?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Marouane Ait Lahcen; Mohamed Adardour; Salma Mortada; Mehdi Oubahmane; Samir Hmaimou; Mohamed Loughzail; Ismail Hdoufane; Sanae Lahmidi; My El Abbes Faouzi; Driss Cherqaoui; Joel T. Mague; Abdesselam Baouid
- Publisher
- Informa UK Limited
- Published
- 2024
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)