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Inhibitory effects of green tea catechins on protein tyrosine phosphatase in Prevotella intermedia by M. Okamoto; K.‐P. Leung; T. Ansai; A. Sugimoto; N. Maeda is a Dentistry article available to read on EtoBox.

What is Inhibitory effects of green tea catechins on protein tyrosine phosphatase in Prevotella intermedia about?

Members of the __Prevotella intermedia__ group possess protein tyrosine phosphatase (PTPase). The purpose of this study was to investigate the effects of catechin derivatives from Japanese green tea on the activity of PTPase in __P.__ __intermedia__ and related organisms. Multilocus enzyme electrophoresis of alkaline phosphatase derived from __P. intermedia__, __Prevotella nigrescens__, __Prevotella pallens__ and __Porphyromonas gingivalis__ revealed a species‐specific migration pattern. Among the tea catechin derivatives tested, (–)‐epigallocatechin gallate (EGCg), similar to orthovanadate, a specific inhibitor for PTPase, was effective in inhibiting the PTPase activity in __P.__ __intermedia__ at 0.5 μm, and related species at 5 μm. The results suggested that the inhibitory effect observed is due to the presence of galloyl moiety in the structure. In contrast, neither the green tea catechins nor orthovanadate inhibited the phosphatase activity in __P.__ __gingivalis__, suggesting that this organism possessed a different family of alkaline phosphatase.

Who reads Inhibitory effects of green tea catechins on protein tyrosine phosphatase in Prevotella intermedia?

Author

M. Okamoto; K.‐P. Leung; T. Ansai; A. Sugimoto; N. Maeda

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0055)

Published

2003

Language

EN

Field

Dentistry (Health Sciences)