Can I read Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins on EtoBox?
Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins by Richard Tremblay; Alain Bonnardeaux; David Geadah; Lambert Busque; Michel Lebrun; Denis Ouimet; Martine Leblanc is a Medicine article available to read on EtoBox.
What is Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins about?
## Background: High-efficiency hemodialysis may induce a deficiency in hydrosoluble vitamins. supplementation with b-complex vitamins has been shown to lower serum homocysteine concentrations in several groups, but relatively few studies have concerned hemodialysis patients. our objectives were to determine the status in b-complex vitamins in a large cohort of unsupplemented hemodialysis patients and to assess the effects of supplementation with hydrosoluble vitamins on serum homocysteine over one year. ## Methods: Serum total homocysteine (thcy), vitamin b12, folate, pyridoxal-5'-phosphate (p-5'-p; the active moiety of vitamin b6), as well as red blood cell folate concentrations, were measured in 168 chronic dialysis patients on three times weekly high-efficiency hemodialysis and not supplemented with hydrosoluble vitamins. their methylenetetrahydrofolate reductase c677t (mthfr) genotypes were also determined (homozygotes tt, heterozygotes ct, without mutation cc). all involved patients were then supplemented with hydrosoluble vitamins (once daily by mouth, diavite; r&d laboratories, minneapolis, mn, usa), and half of them were randomized to receive in addition 10 mg intravenously
Who reads Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Richard Tremblay; Alain Bonnardeaux; David Geadah; Lambert Busque; Michel Lebrun; Denis Ouimet; Martine Leblanc
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)