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Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India by Katiyar, Amit; Sharma, Priyanka; Dahiya, Sushila; Singh, Harpreet; Kapil, Arti; Kaur, Punit is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India about?

The development of multidrug resistance in __Salmonella enterica__ serovar Typhi currently forms a major roadblock for the treatment of enteric fever. This poses a major health problem in endemic regions and extends to travellers returning from developing countries. The appearance of fluoroquinolone non-susceptible strains has resulted in use of ceftriaxone as drug of choice with azithromycin being recommended for uncomplicated cases of typhoid fever. A recent sporadic instance of decreased susceptibility to the latest drug regime has necessitated a detailed analysis of antimicrobial resistance genes and possible relationships with their phenotypes to facilitate selection of future treatment regimes. Whole genome sequencing (WGS) was conducted for 133 clinical isolates from typhoid patients. Sequence output files were processed for pan-genome analysis and prediction of antimicrobial resistance genes. The WGS analyses disclosed the existence of fluoroquinolone resistance conferring mutations in __gyrA, gyrB, parC__ and __parE__ genes of all strains. Acquired resistance determining mechanisms observed included __catA1__ genes for chloramphenicol resistance, __dfrA7, dfrA15, sul1__ an

Who reads Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India?

Author

Katiyar, Amit; Sharma, Priyanka; Dahiya, Sushila; Singh, Harpreet; Kapil, Arti; Kaur, Punit

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)