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Control of Mitochondrial Content of Adenine Nucleotides by Submicromolar Calcium Concentrations and Its Relationship to Hormonal Effects. by R C Haynes; R A Picking; W J Zaks is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Control of Mitochondrial Content of Adenine Nucleotides by Submicromolar Calcium Concentrations and Its Relationship to Hormonal Effects. about?
Rat liver mitochondria were incubated at 30 degrees C with 4 mM ATP in a medium similar in electrolyte composition to that of hepatic cytosol. Under these conditions, a net increase in mitochondrial adenine nucleotides was observed that was dependent on the concentration of free Ca2+ [( Ca2+]) in the incubation medium. At 0.2 microM [Ca2+] or less, there was no demonstrable uptake of adenine nucleotides; at 0.4 microM [Ca2+], or greater, net uptake occurred. The calcium-dependent accumulation of nucleotides by mitochondria required Mg2+ in the incubation medium and was insensitive to carboxyatractyloside. The uptake of adenine nucleotides was enhanced by the addition of antimycin A or antimycin A together with oligomycin. Accumulation of nucleotides appeared to be associated with a small increase in mean mitochondrial volume, but the membrane potential was not affected. No uptake or loss of NAD-NADH by mitochondria was detected. Ruthenium red failed to inhibit the calcium-dependent uptake of adenine nucleotides by the mitochondria, indicating that stimulation of this process by Ca2+ does not involve transport of the cation into mitochondria by the Ca2+ uniporter. Because glucagon a
Who reads Control of Mitochondrial Content of Adenine Nucleotides by Submicromolar Calcium Concentrations and Its Relationship to Hormonal Effects.?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- R C Haynes; R A Picking; W J Zaks
- Publisher
- Elsevier BV
- Published
- 1986
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)