Can I read Transient receptor potential channels in rat renal microcirculation: Actions of angiotensin II on EtoBox?

Transient receptor potential channels in rat renal microcirculation: Actions of angiotensin II by Takenaka, Tsuneo; Suzuki, Hiromichi; Okada, Hirokazu; Inoue, Tsutomu; Kanno, Yoshihiko; Ozawa, Yuri; Hayashi, Koichi; Saruta, Takao is a Medicine article available to read on EtoBox.

What is Transient receptor potential channels in rat renal microcirculation: Actions of angiotensin II about?

## Background: This study assessed the calcium-activating mechanisms mediating glomerular arteriolar constriction by angiotensin ii (ang ii). ## Methods: Immunohistochemical and physiological studies were carried out, using antibody against transient receptor potential (trp)-1 and an isolated perfused kidney model. ## Results: Immunohistochemical experiments demonstrated that trp-1 proteins were transcribed on both afferent and efferent arteriolar myocytes. in the first series of physiological experiments, ang ii (0.3 nmol/l) considerably constricted afferent (20.2 +/- 0.9 to 14.9 +/- 0.7 microm) and efferent arterioles (18.4 +/- 0.7 to 14.0 +/- 0.7 microm). the addition of nifedipine (1 micromol/l) restored decrements in afferent (to 20.0 +/- 0.8 microm) but not efferent arteriolar diameters. further administration of skf-96365 (100 micromol/l), a trp channel blocker, reversed efferent arteriolar constriction (to 16.2 +/- 0.8 micromol/l). in the second group, although 2-aminoethoxydiphenyl borate (100 micromol/l), an inhibitor of inositol trisphosphate-induced calcium release (ip3cr), did not alter glomerular arteriolar diameters, it prevented ang ii-induced afferent arteriolar co

Who reads Transient receptor potential channels in rat renal microcirculation: Actions of angiotensin II?

Author

Takenaka, Tsuneo; Suzuki, Hiromichi; Okada, Hirokazu; Inoue, Tsutomu; Kanno, Yoshihiko; Ozawa, Yuri; Hayashi, Koichi; Saruta, Takao

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2002

Language

EN

Field

Medicine (Health Sciences)