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A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines by Christian Freise; Martin Ruehl; Ulrike Erben; Ulf Neumann; Daniel Seehofer; Ki Young Kim; Wolfram Trowitzsch-Kienast; Thorsten Stroh; Martin Zeitz; Rajan Somasundaram is a Medicine article available to read on EtoBox.

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## Background In traditional Chinese and Korean medicine, an aqueous extract derived from wood and bark of the Japanese spice bush __Lindera obtusiloba__ (__L.obtusiloba__) is applied to treat inflammations and chronic liver diseases including hepatocellular carcinoma. We previously demonstrated anti-fibrotic effects of __L.obtusiloba__ extract in hepatic stellate cells. Thus, we here consequently examine anti-neoplastic effects of __L.obtusiloba__ extract on human hepatocellular carcinoma (HCC) cell lines and the signaling pathways involved. ## Methods Four human HCC cell lines representing diverse stages of differentiation were treated with __L.obtusiloba__ extract, standardized according to its known suppressive effects on proliferation and TGF-β-expression. Beside measurement of proliferation, invasion and apoptosis, effects on signal transduction and NF-κB-activity were determined. ## Results __L.obtusiloba__ extract inhibited proliferation and induced apoptosis in all HCC cell lines and provoked a reduced basal and IGF-1-induced activation of the IGF-1R signaling cascade and a reduced transcriptional NF-κB-activity, particularly in the poorly differentiated SK-Hep1 cells. Poi

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Author

Christian Freise; Martin Ruehl; Ulrike Erben; Ulf Neumann; Daniel Seehofer; Ki Young Kim; Wolfram Trowitzsch-Kienast; Thorsten Stroh; Martin Zeitz; Rajan Somasundaram

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6882)

Published

2011

Language

EN

Field

Medicine (Health Sciences)