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Effects of Childhood Obesity and Related Genetic Factors on Precocious Puberty: Protocol for a Multi-center Prospective Cohort Study by Tingting Yu; Ying Yu; Xiaoqing Li; Peng Xue; Xiaodan Yu; Yao Chen; Huijun Kong; Cuilan Lin; Xiumin Wang; Hao Mei; Dan Wang; Shijian Liu is a Medicine article available to read on EtoBox.
What is Effects of Childhood Obesity and Related Genetic Factors on Precocious Puberty: Protocol for a Multi-center Prospective Cohort Study about?
## Background Childhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are four objectives: (1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children’s precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development. ## Methods We will conduct a multi-center prospective cohort study in three cities, which are selected in southern, central, and northern China, respectively. Primary schools in these cities will be selected by a stratified cluster random sampling method. Primary school students from grade 1 to grade 3 (6 to 10 years old) will be selected for the cohort with extensive baseline data collection, including assessment of pubertal development, fa
Who reads Effects of Childhood Obesity and Related Genetic Factors on Precocious Puberty: Protocol for a Multi-center Prospective Cohort Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tingting Yu; Ying Yu; Xiaoqing Li; Peng Xue; Xiaodan Yu; Yao Chen; Huijun Kong; Cuilan Lin; Xiumin Wang; Hao Mei; Dan Wang; Shijian Liu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)