Opening book details…
Can I read Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis on EtoBox?
Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis by Liang Wu; Xiao-Qian Li; Tanvi Goyal; Sean Eddy; Matthias Kretzler; Wen-Jun Ju; Min Chen; Ming-Hui Zhao is a Medicine article available to read on EtoBox.
What is Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis about?
## Introduction The current study aimed to investigate the association between urinary epidermal growth factor (uEGF) and renal disease severity and outcomes in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). ## Methods Intrarenal__EGF__mRNA expression was extracted from transcriptomic data of microdissected tubulointerstitial compartments of kidney biopsies of patients with AAV. uEGF was measured in 173 patients with AAV in active stage and 143 in remission, and normalised to urine creatinine excretion (uEGF/Cr). The association between uEGF/Cr (or__EGF__mRNA) and clinical–pathological parameters was tested using linear regression analysis. The ability of uEGF/Cr to predict renal outcomes was analysed using Cox’s regression analysis. ## Results In patients with AAV, intrarenal__EGF__mRNA expression was significantly associated with estimated glomerular filtration rate (eGFR)(log~2~) at time of biopsy (β=0.63, p<0.001). The level of uEGF/Cr was significantly higher in patients in remission than in patients with active disease, both when looking at patients with sequential measurements (2.75±1.03vs 2.08±0.98, p<0.001) and in cross-sectional comparison.
Who reads Urinary Epidermal Growth Factor Predicts Renal Prognosis in Antineutrophil Cytoplasmic Antibody-associated Vasculitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Liang Wu; Xiao-Qian Li; Tanvi Goyal; Sean Eddy; Matthias Kretzler; Wen-Jun Ju; Min Chen; Ming-Hui Zhao
- Publisher
- BMJ
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)