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Impact of Lung Function on Bronchiolitis Obliterans Syndrome and Outcome after Allogeneic Hematopoietic Cell Transplantation with Reduced-Intensity Conditioning by Jesús Duque-Afonso; Gabriele Ihorst; Miguel Waterhouse; Robert Zeiser; Ralph Wäsch; Hartmut Bertz; Joachim Müller-Quernheim; Jürgen Finke; Reinhard Marks; Antje Prasse is a Medicine article available to read on EtoBox.

What is Impact of Lung Function on Bronchiolitis Obliterans Syndrome and Outcome after Allogeneic Hematopoietic Cell Transplantation with Reduced-Intensity Conditioning about?

Lung function deterioration contributes to treatment-related morbidity and mortality in patients after allogeneic hematopoietic cell transplantation (allo-HCT). Better understanding of impaired lung function including bronchiolitis obliterans syndrome (BOS) as chronic manifestation of graft-versus-host disease (GVHD) might improve outcomes of patients after allo-HCT. To detect early pulmonary function test abnormalities associated with BOS incidence and outcome after allo-HCT, we performed a retrospective analysis of homogenous-treated 445 patients (median age, 61.9 years; range, 19 to 76 years) with a reduced intensity/toxicity conditioning protocol. The cumulative incidence of BOS was 4.1% (95% confidence interval [CI], 2.6 to 6.4) at 1 year and 8.6% (95% CI, 6.3 to 11.6) at 5 years after allo-HCT with a median follow-up of 43.2 months (range, 3.3 to 209 months). In multivariate analysis, pre-existence of moderate small airway disease reflected by decreased midexpiratory flows before allo-HCT was associated with increased risk for BOS development. In addition, severe small airway disease before allo-HCT and combined restrictive/obstructive lung disease at day +100 after allo-HCT

Who reads Impact of Lung Function on Bronchiolitis Obliterans Syndrome and Outcome after Allogeneic Hematopoietic Cell Transplantation with Reduced-Intensity Conditioning?

Author

Jesús Duque-Afonso; Gabriele Ihorst; Miguel Waterhouse; Robert Zeiser; Ralph Wäsch; Hartmut Bertz; Joachim Müller-Quernheim; Jürgen Finke; Reinhard Marks; Antje Prasse

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1083-8791)

Published

2018

Language

EN

Field

Medicine (Health Sciences)