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Can I read Brain and Cord Myelin Water Imaging: a Progressive Multiple Sclerosis Biomarker on EtoBox?
Brain and Cord Myelin Water Imaging: a Progressive Multiple Sclerosis Biomarker by Shannon Kolind; Arshia Seddigh; Anna Combes; Bretta Russell-Schulz; Roger Tam; Vignan Yogendrakumar; Sean Deoni; Naomi A. Sibtain; Anthony Traboulsee; Steven C.R. Williams; Gareth J. Barker; Peter A. Brex is a Medicine article available to read on EtoBox.
What is Brain and Cord Myelin Water Imaging: a Progressive Multiple Sclerosis Biomarker about?
## Objectives Conventional magnetic resonance imaging (MRI) is used to diagnose and monitor inflammatory disease in relapsing remitting (RR) multiple sclerosis (MS). In the less common primary progressive (PP) form of MS, in which focal inflammation is less evident, biomarkers are still needed to enable evaluation of novel therapies in clinical trials. Our objective was to characterize the association — across the brain and cervical spinal cord — between clinical disability measures in PPMS and two potential biomarkers (one for myelin, and one for atrophy, both resulting from the same imaging technique). ## Methods Multi-component driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) MRI of the brain and cervical spinal cord were obtained for 15 PPMS patients and 11 matched controls. Data were analysed to estimate the signal related to myelin water (VF~M~), as well as volume measurements. MS disability was assessed using the Multiple Sclerosis Functional Composite score, which includes measures of cognitive processing (Paced Auditory Serial Addition Test), manual dexterity (9-Hole Peg Test) and ambulatory function (Timed 25-Foot Walk); and the Expanded Disability Stat
Who reads Brain and Cord Myelin Water Imaging: a Progressive Multiple Sclerosis Biomarker?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shannon Kolind; Arshia Seddigh; Anna Combes; Bretta Russell-Schulz; Roger Tam; Vignan Yogendrakumar; Sean Deoni; Naomi A. Sibtain; Anthony Traboulsee; Steven C.R. Williams; Gareth J. Barker; Peter A. Brex
- Publisher
- Elsevier BV
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)