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The HCV ARFP/F/core+1 protein: Production and functional analysis of an unconventional viral product by Niki Vassilaki; Penelope Mavromara is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Hepatitis C virus (HCV) is an enveloped positive‐strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV protein has also been identified by our laboratory and others. This protein—known as ARFP (alternative reading frame protein), F (for frameshift) or core+1 (to indicate the position) protein ‐ is synthesized by an open reading frame overlapping the core gene at nucleotide +1 (core+1 ORF). However, almost 10 years after its discovery, we still know little of the biological role of the ARFP/F/core+1 protein. Abolishing core+1 protein production has no affect on HCV replication in cell culture or uPA‐SCID mice, suggesting that core+1 protein is probably not important for the HCV reproductive cycle. However, the detection of specific anti‐core+1 antibodies and T‐cell responses in HCV‐infected patients, as reported by many independent laboratories, provides strong evidence that this protein is produced __in vivo__. Furthermore, analyses of the HCV sequences isolate

Who reads The HCV ARFP/F/core+1 protein: Production and functional analysis of an unconventional viral product?

Author

Niki Vassilaki; Penelope Mavromara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; Informa UK Limited (ISSN 1521-6543)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)