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Intentional Iron Overdose in Pregnancy--management and Outcome by Thao Tran; Joseph R Wax; Christine Philput; Joy D Steinfeld; Charles J Ingardia is a Medicine article available to read on EtoBox.

What is Intentional Iron Overdose in Pregnancy--management and Outcome about?

The objectives of our study were to 1) determine if peak maternal serum iron level or toxicity stage after intentional overdose is associated with adverse maternal-fetal outcome, and 2) describe the use of deferoxamine antidote therapy in obstetric patients. A computer search of the English language literature from 1966-1998 used the key words iron toxicity, iron poisoning, deferoxamine, and pregnancy to identify peer-reviewed papers reporting intentional iron overdoses in pregnancy. Two investigators independently extracted data from articles and their references including stage of toxicity (0 = asymptomatic, 1 = gastrointestinal symptoms, 2 = metabolic disturbance, 3 = organ failure), with differences resolved by consensus. Statistical analysis used the Student t-test, Fisher exact test, or ANOVA, as appropriate. Fourteen publications were identified, describing 61 cases of obstetric iron overdose, including one recent case at our institution. Compared with women who had lower peak levels, women with peak serum iron levels > or =400 mcg/dL were more frequently symptomatic (12/13 vs. 5/10, respectively, p = 0.05). Peak iron level > or =400 mcg/dL was not associated with increased

Who reads Intentional Iron Overdose in Pregnancy--management and Outcome?

Author

Thao Tran; Joseph R Wax; Christine Philput; Joy D Steinfeld; Charles J Ingardia

Publisher

Elsevier BV

Published

2000

Language

EN

Field

Medicine (Health Sciences)