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Role of Sensory Activity on Chemospecific Populations of Interneurons in the Adult Olfactory Bulb by Pierre-Olivier Bastien-Dionne; Linda S. David; André Parent; Armen Saghatelyan is a Neuroscience article available to read on EtoBox.

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## Abstract The olfactory bulb (OB) retains a remarkable capacity to renew its interneuronal populations throughout the lifespan of animals. Neuronal precursors giving rise to the bulbar interneurons are generated in the subventricular zone and have to migrate long distances before reaching the OB. In the adult OB these neuronal precursors differentiate into distinct neuronal types, including GABAergic cells located in the granule cell layer and a diverse set of neurons in the glomerular layer comprising GABAergic and dopaminergic interneurons, as well as other neuronal subtypes expressing calretinin and calbindin. While the role of sensory activity in the integration and/or survival of newly generated cells in the olfactory system is well established, very little is known about how odorant‐induced activity affects fate specification of newborn cells as well as survival and fate maintenance of preexisting neuronal populations generated in adulthood. The present study demonstrates that sensory deprivation diminishes not only the number of newborn cells in the OB, but also reduces the density of granule and periglomerular cells generated before nostril occlusion. It also shows that s

Who reads Role of Sensory Activity on Chemospecific Populations of Interneurons in the Adult Olfactory Bulb?

Author

Pierre-Olivier Bastien-Dionne; Linda S. David; André Parent; Armen Saghatelyan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2010

Language

EN

Field

Neuroscience (Life Sciences)