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Can I read A doxorubicin-Pt(II) complex. Chemistry and antitumor activity on EtoBox?
A doxorubicin-Pt(II) complex. Chemistry and antitumor activity by A. Pasini; G. Pratesi; G. Savi; F. Zunino is a Chemistry article available to read on EtoBox.
What is A doxorubicin-Pt(II) complex. Chemistry and antitumor activity about?
Compound 1, cis-[Pt&(Dx)(tba)] , where Dx is Ncoordinated doxorubicin and tba is tert-butylamine, is active against murine P388 and murine L1210 leukemias, including cisplatin-and doxorubicinresistant sublines, but against a Dx-resistant solid tumor its activity resembles that of doxorubicin. Preliminary results, based on circular dichroism spectroscopy, suggest that 1 interacts with DNA mainly by intercalation of the Dx moiety, rather than by covalent binding of Pt.
Who reads A doxorubicin-Pt(II) complex. Chemistry and antitumor activity?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- A. Pasini; G. Pratesi; G. Savi; F. Zunino
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-1693)
- Published
- 1987
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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