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Clonal change of carbapenem-resistant Acinetobacter baumannii isolates in a Korean hospital by So Hyun Jun; Da Eun Lee; Hye Ryeong Hwang; Nayeong Kim; Hyo Jeong Kim; Yoo Chul Lee; Yu Kyung Kim; Je Chul Lee is a Medicine article available to read on EtoBox.

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The expansion of specific carbapenem-resistant Acinetobacter baumannii (CRAB) clones is a global concern due to its therapeutic difficulty and epidemicity. To understand the prevalence of CRAB isolates in a Korean hospital, we investigated the epidemiological characteristics of 96 CRAB isolates between 2016 and 2018, including the sequence types (STs), antimicrobial susceptibility, and genetic background of resistance to carbapenems and aminoglycosides. Six STs were identified using the Oxford multilocus sequence typing scheme; ST191 (n = 8), ST208 (n = 12), ST229 (n = 11), and ST369 (n = 21) were previously identified clones in the study hospital, whereas gpi variants of ST208, ST451 (n = 34) and ST784 (n = 10), were emerging clones. ST208 isolates exhibited higher resistance rates to minocycline than other ST isolates, whereas ST369 isolates exhibited lower resistance rates to aminoglycosides and trimethoprim/sulfamethoxazole than other ST isolates. All CRAB isolates previously isolated in the study hospital carried ISAbaI-bla OXA-23 for carbapenem resistance, but 10 ST229 isolates carried only ISAbaI-bla OXA-51 . The carriage of armA was lower in ST369 isolates (38%) than in oth

Who reads Clonal change of carbapenem-resistant Acinetobacter baumannii isolates in a Korean hospital?

Author

So Hyun Jun; Da Eun Lee; Hye Ryeong Hwang; Nayeong Kim; Hyo Jeong Kim; Yoo Chul Lee; Yu Kyung Kim; Je Chul Lee

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)