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Prebiotic supplementation modulates advanced glycation end-products (AGEs), soluble receptor for AGEs (sRAGE), and cardiometabolic risk factors through improving metabolic endotoxemia: a randomized-controlled clinical trial by Mahdieh Abbasalizad Farhangi; Parvin Dehghan; Nazli Namazi is a Medicine article available to read on EtoBox.

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## Purpose: The oxidative stress plays a key role in the initiation, propagation, and development of the complications of type 2 diabetes mellitus (t2dm). this trial aimed to evaluate the effects of resistant dextrin as a prebiotic on the cardiometabolic risk factors and the status of oxidative stress in patients with t2dm. ## Methods: Sixty-five female subjects with t2dm were assigned to either the intervention (n = 33) or control (n = 32) groups receiving 10 g/day of resistant dextrin or placebo, respectively, for 8 weeks. fasting blood samples were collected at baseline and post-intervention to determine the serum levels of glycemic indices, lipid profile, atherogenic indices, and soluble receptor for ages (srage), carboxymethyl lysine (cml), pentosidine, malondialdehyde (mda), 8-iso-prostaglandin f2α (8-iso-pgf2α), total antioxidant capacity (tac), antioxidant enzymes activity, and uric acid. data were analyzed using spss software 17. paired, unpaired student's t tests, and analysis of covariance were used to compare the quantitative variables. ## Results: Resistant dextrin caused a significant decrease in fpg (- 17.43 mg/dl, 9.80%), tg (- 40.25 mg/dl, 23.01%), tc/hdl (- 0.80,

Who reads Prebiotic supplementation modulates advanced glycation end-products (AGEs), soluble receptor for AGEs (sRAGE), and cardiometabolic risk factors through improving metabolic endotoxemia: a randomized-controlled clinical trial?

Author

Mahdieh Abbasalizad Farhangi; Parvin Dehghan; Nazli Namazi

Publisher

Springer; Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Science and Business Media LLC (ISSN 1436-6207)

Published

2019

Language

EN

Field

Medicine (Health Sciences)