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Stromal cell‐derived factor‐1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor by Krishna Reddy; Zhichao Zhou; Shu‐Fang Jia; Tim H. Lee; Jaime Morales‐Arias; Ying Cao; Eugenie S. Kleinerman is a Medicine article available to read on EtoBox.
What is Stromal cell‐derived factor‐1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor about?
## Abstract Stromal cell‐derived Factor‐1α (SDF‐1α) stimulates the migration of bone marrow (BM) cells, similar to vascular endothelial growth factor (VEGF). We previously demonstrated that inhibition of VEGF~165~ by small interfering RNA inhibited Ewing's sarcoma tumor growth, tumor vessel formation and recruitment of BM cells to the tumor. To determine the importance of BM cells in tumor vessel development, we investigated the effects of SDF‐1α on VEGF‐inhibited TC/siVEGF~7‐1~ Ewing's tumor neovasculature formation and growth. The effect of SDF‐1α on CD34^+^ progenitor cell chemotaxis was determined __in vivo__. Using a BM transplantation model with GFP^+^ transgenic mice as BM donors and nude mice as recipients, we evaluated the effect of SDF‐1α on the recruitment of BM‐derived cells to VEGF~165~‐inhibited TC/siVEGF~7‐1~ tumors, as well as its effect on neovasculature development, vessel morphology and tumor growth. SDF‐1α stimulated the migration of CD34^+^ progenitor cells to Matrigel plugs __in vivo__ and promoted the retainment of BM‐derived pericytes in close association with perfused, functional tumor vessels. Intratumor inoculation of Ad‐SDF‐1α into TC/siVEGF~7‐1~ tumors
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- Author
- Krishna Reddy; Zhichao Zhou; Shu‐Fang Jia; Tim H. Lee; Jaime Morales‐Arias; Ying Cao; Eugenie S. Kleinerman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)