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Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis by Tiberiu A. Pana; Mohsen Dehghani; Hamid Reza Baradaran; Samuel R. Neal; Adrian D. Wood; Chun Shing Kwok; Yoon K. Loke; Robert N. Luben; Mamas A. Mamas; Kay-Tee Khaw; Phyo Kyaw Myint is a Medicine article available to read on EtoBox.
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## Abstract The role of dietary calcium in cardiovascular disease prevention is unclear. We aimed to determine the association between calcium intake and incident cardiovascular disease and mortality. Data were extracted from the European Prospective Investigation of Cancer, Norfolk (EPIC-Norfolk). Multivariable Cox regressions analysed associations between calcium intake (dietary and supplemental) and cardiovascular disease (myocardial infarction, stroke, heart failure, aortic stenosis, peripheral vascular disease) and mortality (cardiovascular and all-cause). The results of this study were pooled with those from published prospective cohort studies in a meta-analsyis, stratifying by average calcium intake using a 700 mg/day threshold. A total of 17,968 participants aged 40–79 years were followed up for a median of 20.36 years (20.32–20.38). Compared to the first quintile of calcium intake (< 770 mg/day), intakes between 771 and 926 mg/day (second quintile) and 1074–1254 mg/day (fourth quintile) were associated with reduced all-cause mortality (HR 0.91 (0.83–0.99) and 0.85 (0.77–0.93), respectively) and cardiovascular mortality [HR 0.95 (0.87–1.04) and 0.93 (0.83-1.04)]. Compared
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- Author
- Tiberiu A. Pana; Mohsen Dehghani; Hamid Reza Baradaran; Samuel R. Neal; Adrian D. Wood; Chun Shing Kwok; Yoon K. Loke; Robert N. Luben; Mamas A. Mamas; Kay-Tee Khaw; Phyo Kyaw Myint
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)