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Can I read The Role of Carboxylesterase in Species Variation of Oxime Protection Against Soman on EtoBox?
The Role of Carboxylesterase in Species Variation of Oxime Protection Against Soman by Donald M. Maxwell; Karen M. Brecht is a Neuroscience article available to read on EtoBox.
What is The Role of Carboxylesterase in Species Variation of Oxime Protection Against Soman about?
Oxime protection against soman, a highly toxic anticholinesterase agent, was examined in mice and guinea pigs. The maximal protection produced by the oximes PAM and HI-6 varied as much as 6-fold between these species. Since endogenous carboxylesterase (CaE) is known to be an important determinant of species variation in soman toxicity, the protection of PAM and HI-6 against soman was also measured in animals whose endogenous CaE was inhibited with cresylbenzodioxaphosphorin oxide. In CaE-inhibited animals the soman LD50 values were similar in unprotected mice and guinea pigs (10.2 vs. 12.2 micrograms/kg) and oxime-protected mice and guinea pigs (38.1 vs. 40.3 micrograms/kg for PAM; 159 vs. 151 micrograms/kg for HI-6). The levels of oxime protection observed in CaE-inhibited animals agreed with previous experiments in other species that have no endogenous plasma CaE. The 4-5 times greater in vivo protection against soman of HI-6 vs. PAM in CaE-inhibited animals correlated with in vitro experiments in which HI-6 produced 3-5 times more oxime reactivation of soman-inhibited AChE than PAM.
Who reads The Role of Carboxylesterase in Species Variation of Oxime Protection Against Soman?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Donald M. Maxwell; Karen M. Brecht
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0149-7634)
- Published
- 1991
- Language
- EN
- Field
- Neuroscience (Life Sciences)