Can I read Disposition of Histamine, Its Metabolites, and pros ‐Methylimidazoleacetic Acid in Brain Regions of Rats Chronically Infused with α‐Fluoromethylhistidine on EtoBox?

Disposition of Histamine, Its Metabolites, and pros ‐Methylimidazoleacetic Acid in Brain Regions of Rats Chronically Infused with α‐Fluoromethylhistidine by George D. Prell; Erwin Douyon; William F. Sawyer; Albert Marcus Morrishow is a Neuroscience article available to read on EtoBox.

What is Disposition of Histamine, Its Metabolites, and pros ‐Methylimidazoleacetic Acid in Brain Regions of Rats Chronically Infused with α‐Fluoromethylhistidine about?

Abstract: In mammalian brain, histamine is known to be metabolized solely by histamine methyltransferase (HMT), forming __tele__‐methylhistamine (t‐MH), then __tele__‐methylimidazoleacetic acid (t‐MIAA). We previously showed that imidazoleacetic acid (IAA), a GABA agonist, and histamine's metabolite in the periphery, is present in brain where its concentration increased after inhibition of HMT. Also, when [^3^H]histamine was given intracerebroventricularly to rats, a portion was converted to IAA, a process increased by inhibition of HMT. These results indicated that brain has the capacity to oxidize histamine but did not show whether this pathway is operative under physiological conditions. To address this question, rats were infused for >4 weeks with α‐fluoromethylhistidine (α‐FMHis), an irreversible inhibitor of histamine's synthetic enzyme, l‐histidine decarboxylase. Compared with controls (untreated and saline‐treated rats), brain levels of histamine, t‐MH, and t‐MIAA in all regions were markedly reduced in treated rats. As a percentage of controls, depletion of t‐MIAA > t‐MH > histamine in all regions, and regional depletions of histamine corresponded to its turnover rates in

Who reads Disposition of Histamine, Its Metabolites, and pros ‐Methylimidazoleacetic Acid in Brain Regions of Rats Chronically Infused with α‐Fluoromethylhistidine?

Author

George D. Prell; Erwin Douyon; William F. Sawyer; Albert Marcus Morrishow

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)