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Genotyping of samples lacking expected antibodies in ABO blood group by Zhi‐Hui Deng; Jian‐Qiang Zeng; Qiong Yu; Yu‐Qing Su; Yan‐Lian Liang; Liang Lu; Wei‐Gang Zhu; Bao‐Cheng Yang is a Medicine article available to read on EtoBox.
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## Abstract We report nine donations with ABO inconsistency in reverse typing caused by partly or entirely missing antibodies. A and B antigens and antibodies were examined by serological blood typing, and ABO deoxyribonucleic acid (DNA) analyses were performed by sequence‐specific priming and sequencing. A __B101__ allele was demonstrable in a case with O phenotype. The molecular mechanisms in deficiency of natural ABO antibody could be partly clarified. The ABO genotyping technique is an accurate method for determining the blood samples involved in ABO grouping discrepancies and is a valuable complement to serology for correct determination of donor blood status. The mechanisms involved in the absence of potent natural antibodies directed against A and B antigen lacking on an individual's own red cell membranes remain to be further investigated. J. Clin. Lab. Anal. 21:363–366, 2007. © 2007 Wiley‐Liss, Inc.
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- Author
- Zhi‐Hui Deng; Jian‐Qiang Zeng; Qiong Yu; Yu‐Qing Su; Yan‐Lian Liang; Liang Lu; Wei‐Gang Zhu; Bao‐Cheng Yang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-8013)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)