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Can I read Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 Years on EtoBox?
Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 Years by James Fung; Ching-Lung Lai; John Yuen; Charles Cheng; Ringo Wu; Danny Ka-Ho Wong; Wai-Kay Seto; Ivan Fan-Ngai Hung; Man-Fung Yuen is a Medicine article available to read on EtoBox.
What is Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 Years about?
We aimed to determine the 2-year outcomes of entecavir followed by lamivudine in patients with undetectable viral load ( 20 IU/mL, occurring at a range of 12 to 96 weeks. Of these, four patients had HBV DNA of less than 100 IU/mL during rebound (three had undetectable HBV DNA after switching back to entecavir), and the remaining two patients had HBV DNA levels of 7,973 and 699 IU/mL. Three patients (12%) had evidence of drug-resistant mutations, of which two patients had rtM204I mutation and one patient had rtM204V mutation. One of these three patients had previous lamivudine exposure before entecavir treatment and one patient had questionable drug compliance. Conclusion: Sequential therapy using entecavir followed by lamivudine resulted in virological rebound in 24% of patients after 96 weeks. Prior optimal viral suppression with entecavir did not confer any significant advantage in patients who switched to lamivudine. (HEPATOLOGY 2011;53:1148-1153) C hronic hepatitis B (CHB) affects 400 million people worldwide, constituting an important health burden in areas where hepatitis B virus (HBV) infection is endemic. Up to 40% of CHB patients may develop cirrhosis and its complications
Who reads Randomized trial of lamivudine versus entecavir in entecavir-treated patients with undetectable hepatitis B virus DNA: Outcome at 2 Years?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- James Fung; Ching-Lung Lai; John Yuen; Charles Cheng; Ringo Wu; Danny Ka-Ho Wong; Wai-Kay Seto; Ivan Fan-Ngai Hung; Man-Fung Yuen
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)