Can I read P75 Neurotrophin Receptor Functions as a Survival Receptor in Brain-metastatic Melanoma Cells on EtoBox?

P75 Neurotrophin Receptor Functions as a Survival Receptor in Brain-metastatic Melanoma Cells by Dario Marchetti; Rebecca Aucoin; Jason Blust; Brian Murry; Andrea Greiter-Wilke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is P75 Neurotrophin Receptor Functions as a Survival Receptor in Brain-metastatic Melanoma Cells about?

## Abstract The p75 neurotrophin receptor (p75^NTR^), a common receptor for members of the neurotrophins (NT) family, was previously identified as a molecular determinant of brain metastasis. We have also reported that NT treatment of murine and human brain‐metastatic melanoma cells affects their invasive capacities and increases the production of heparanase, an important and unique extracellular matrix (ECM) degradative enzyme. Neurotrophism can be a survival‐support mechanism for brain‐metastatic cells and a survival assay was devised to mimic the growth limiting conditions of rapidly expanding metastatic tumors prior to neoangiogenesis. We report that p75^NTR^ promoted the survival of brain‐metastatic melanoma cells but not melanocytes in stress cultures conditions. Secondly, melanoma cells fluorescently sorted for high p75^NTR^ expression (p75^NTR‐H^ cells) had an up to a 15‐fold greater survival than those sorted for low p75^NTR^ expression (p75^NTR‐L^ cells). Thirdly, cells overexpressing p75^NTR^ associated with the growth fraction and provided these cells with an inherent growth advantage. Finally, we observed an increased survival of sorted p75^NTR‐L^ cells, dependent upon

Who reads P75 Neurotrophin Receptor Functions as a Survival Receptor in Brain-metastatic Melanoma Cells?

Author

Dario Marchetti; Rebecca Aucoin; Jason Blust; Brian Murry; Andrea Greiter-Wilke

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)