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The study focuses on the synthesis and evaluation of C15 triene urushiol derivatives as potential anticancer agents and HDAC2 inhibitors. Among the synthesized compounds, compound 1 demonstrated significant anti-HepG2 activity with an IC50 of 7.886 µM, while also enhancing apoptosis in HepG2 cells. The findings suggest that these derivatives could serve as effective treatments for liver cancer by targeting HDAC2.
- Author
- Kosana Sai Chaitanya
- Language
- EN