Can I read Self-assembled Protein-drug Nanoparticles for Enhanced Drug Delivery and Targeting Cancer Therapeutics on EtoBox?

Self-assembled Protein-drug Nanoparticles for Enhanced Drug Delivery and Targeting Cancer Therapeutics by Islam A. Hassanin; Mohamed Teleb; Adnan A. Bekhit; Kadria A. Elkhodairy; Sherine N. Khattab; Ahmed O. Elzoghby is a book available to read on EtoBox.

What is Self-assembled Protein-drug Nanoparticles for Enhanced Drug Delivery and Targeting Cancer Therapeutics about?

Nanoparticles are a versatile group of nano-sized materials, offering the advantage of the delivery of therapeutic and diagnostic agents (Murthy, 2007). They are preferred drug delivery systems, owing to their small particle size, which can be internalized and accumulated in diseased tissues, for example, Cancer tissue. The characteristics of the nanoparticles allow their enhanced permeability and retention (EPR) in the tumor cells, by evading the systemic circulation through the fenestrations of the angiogenic blood vessels (Greish, 2010). Subsequently, nanocarriers evade potential off-target toxicity, which may compromise the therapeutic goals of multiple anticancer drugs (De Jong & Borm, 2008). Generally, the nanocarrier systems, that are involved in drug delivery, are categorized into organic and inorganic nanoparticles. Organic nanocarriers are more preferred, due to their less toxic profile, and the capacity of functionalization with targeting materials, in addition to high drug loading capacity (Fang et al., 2020;Khalid et al., 2020). Several organic nanocarriers are investigated. For instance, lipid-based nanoparticles, polymeric nanoparticles, and more importantly, protein

Author

Islam A. Hassanin; Mohamed Teleb; Adnan A. Bekhit; Kadria A. Elkhodairy; Sherine N. Khattab; Ahmed O. Elzoghby

Publisher

Elsevier Science & Technology

Published

2023

Language

EN

ISBN

9780323857857