Can I read Small-Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag on EtoBox?

Small-Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag by Jens Ripcke; Kim Zarse; Michael Ristow; Marc Birringer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Small-Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag about?

## Abstract **Reversible mitochondrial shuttle**: A novel concept in mitochondrial pharmacology allows the transport of bioactive compounds into the mitochondrial compartment and their subsequent release. A lipoic acid derivative containing a cleavable (“reversible”) triphenylphosphonium tag is endogenously cleaved by the mitochondrial aldehyde dehydrogenase (ALDH‐2) after mitochondrial accumulation.magnified image __Targeted accumulation of chemically unaltered compounds within the mitochondrial compartment has not yet been achieved. Here we describe a reversible tag that is endogenously cleaved after mitochondrial accumulation has occurred. Specifically, we have reversibly tagged__ α__‐lipoic acid with a triphenylphosphonium moiety that is cleaved by the physiologically contained mitochondrial aldehyde dehydrogenase (ALDH‐2). This reversibly tagged compound activates the lipoic acidsensitive pyruvate dehydrogenase complex, and this results in increased glucose oxidation. We observed a reduction in ROS accumulation after preincubation with the reversibly tagged compound, whereas untagged or irreversibly tagged compounds either had no effect on ROS formation or rather caused increa

Who reads Small-Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag?

Author

Jens Ripcke; Kim Zarse; Michael Ristow; Marc Birringer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1439-4227)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)